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pentobarbital will lessen the level or impact of methadone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.pentobarbital decreases effects of sufentanil SL by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Coadministration of CYP3A4 inducers might lessen sufentanil amounts and effi